Decisions regarding choice of wound treatment involve two basic considerations: 1 how safe is the treatment, and 2 how effective is the treatment. The efficacy of a wound care treatment e. The task of evaluating the choice of povidone-iodine solution for treatment of wounds, especially the chronic wounds most often seen in physical therapy practice, is made complex by two factors. All patients completed the study, and none required hospital admission.
Compared with the control group, patients in the intervention group were younger Table. Median IQR age of patients in the control group was 57 years and in the intervention group was 33 years. All patients but 1 had negative viral titer by day 3. All patients exposed to PI experienced unpleasant nasal tingling but completed the study. Thyroid stimulating hormone elevation median [IQR], 3. No modification in thyroid hormone T3, T4 or creatinine levels was observed. Limitations include the small number of patients and the single-center design.
These data call for a larger clinical trial to confirm the benefit of PI in limiting the excretion and resulting human-to-human transmission of SARS-CoV-2, using lower PI concentrations to minimize adverse effects. Published Online: February 4, Author Contributions: Dr Guenezan had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Administrative, technical, or material support: Guenezan, Garcia, Jousselin. No other disclosures were reported. This study did not benefit from financial support. Data Sharing Statement: See Supplement 2. There was no financial compensation for these contributions. Trial Registration: ClinicalTrials. Our website uses cookies to enhance your experience. Article PubMed Google Scholar. Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.
Clin Infect Dis. Preparing for a COVID pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore. Article Google Scholar. Treasure Island: StatPearls; Google Scholar. Crit Care Med. Antiseptics in the era of bacterial resistance: a focus on povidone iodine.
Clinical Practice. In vitro short-time killing activity of povidone-iodine Isodine gargle in the presence of oral organic matter. Practical use of povidone-iodine antiseptic in the maintenance of oral health and in the prevention and treatment of common oropharyngeal infections. Int J Clin Pract. Mechanisms of the action of povidone-iodine against human and avian influenza a viruses: its effects on hemagglutination and sialidase activities. Virol J. Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents.
Infect Dis Ther. Eggers M. Infectious disease management and control with Povidone iodine. Inactivation of human immunodeficiency virus by Betadine products and chlorhexidine. J Acquir Immune Defic Syndr CAS Google Scholar. Inactivation of human viruses by povidone-iodine in comparison with other antiseptics. Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study. BMC Oral Health.
Prevention of upper respiratory tract infections by gargling: a randomized trial. Am J Prev Med. Cost-effectiveness of gargling for the prevention of upper respiratory tract infections. Prevention of respiratory infections by povidone-iodine gargle. Shiraishi T, Nakagawa Y. Evaluation of the bactericidal activity of povidone-iodine and commercially available gargle preparations.
Gargling with povidone-iodine reduces the transport of bacteria during oral intubation. Can J Anaesth. Interstitial pneumonitis after betadine aspiration.
J Craniofac Surg. Aspiration pneumonitis due to Povidone-iodine aspiration during a facial bone fracture reduction operation. Lithgow K, Symonds C.
Severe thyrotoxicosis secondary to Povidone-iodine from peritoneal dialysis. Case Rep Endocrinol. Povidone iodine-induced overt hypothyroidism in a patient with prolonged habitual gargling: urinary excretion of iodine after gargling in normal subjects. Intern Med. The effect of three mouthwashes on radiation-induced oral mucositis in patients with head and neck malignancies: a randomized control trial.
J Cancer Res Ther. Eur Ann Allergy Clin Immunol. Anaphylaxis to polyvinylpyrrolidone in povidone-iodine for impetigo contagiosum in a boy with atopic dermatitis. Int Arch Allergy Immunol. Acute kidney injury due to povidone-iodine ingestion. Acute hemolysis following iodine tincture ingestion.
Hum Exp Toxicol. J Clin Exp Dent.
0コメント