Most of these eggs are stored in a hidden pool to prevent all the eggs from ovulating at once. The number of eggs hidden away is correlated with the FSH value on the second or third day of your cycle. A high FSH means that there are fewer eggs available. FSH measurement, via blood collected from a vein, must happen on the 2nd or 3rd day of menses because it is most accurate when estrogen is at its lowest point.
Elevated estrogen may artificially lower your FSH and give a false reading. Women who no longer get their cycles always have low estrogen and therefore FSH can be measured at any point. Remember that FSH levels in your blood detects the health of the ovary and is not the cause of the problem. Relationship of follicle numbers, estradiol levels to multiple implantation in intrauterine insemination cycles. Risk factors for high-order multiple pregnancy and multiple birth after controlled ovarian hyperstimulation: results of intrauterine insemination cycles.
Multiple birth resulting from ovarian stimulation for subfertility treatment. Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins. Further considerations on natural or mild hyperstimulation cycles for intrauterine insemination treatment: effects on pregnancy and multiple pregnancy rates.
Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network.
Low dose exogenous FSH initiated during the early, mild or late follicular phase can induce multiple dominant follicle development. Low-dose FSH therapy for anovulatory infertility associated with polycystic ovary syndrome: rationale, results, reflections and refinements.
A randomised controlled trial of three low-dose gonadotrophin protocols for unexplained infertility. Sequential step-up and step-down dose regimen: an alternative method for ovulation induction with follicle stimulating hormone in polycystic ovary syndrome. Main inhibitor of follicle stimulating hormone in the luteal-follicular transition: inhibin A, oestradiol, or inhibin B?
The follicle-stimulating hormone threshold level for follicle maturation in superovulated cycles. Low dose recombinant FSH treatment may reduce multiple gestations caused by controlled ovarian hyperstimulation and intrauterine insemination.
GnRH antagonists and mild ovarian stimulation for intrauterine insemination: a randomized study comparing different gonadotrophin dosages. Follicular diameters in conception cycles with and without multiple pregnancy after stimulated ovulation induction. Lack of correlation between maximum early follicular phase serum follicle stimulating hormone concentrations and menstrual cycle characteristics in women under the age of 35 years. The clinical efficacy of low-dose step-up follicle stimulating hormone administration for treatment of unexplained infertility.
Follicular size at the time of human chorionic gonadotropin administration predicts ovulation outcome in human menopausal gonadotropin-stimulated cycles. Determinants of the outcome of intrauterine insemination: analysis of outcomes of consecutive cycles. Risk factors for high-order multiple implantation after ovarian stimulation with gonadotrophins: evidence from a large series of consecutive pregnancies in a single centre.
Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotrophins.
Van Rumste. Is controlled ovarian stimulation in intrauterine insemination an acceptable therapy in couples with unexplained non-conception in the perspective of multiple pregnancies? All rights reserved. For Permissions, please email: journals. Issue Section:. Download all slides.
View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert. Receive exclusive offers and updates from Oxford Academic. More on this topic Treatment of anovulatory infertility: the problem of multiple pregnancy. Pituitary—ovarian axis during lactational amenorrhoea.
Longitudinal assessment of follicular growth, gonadotrophins, sex steroids and inhibin levels before and after recovery of menstrual cyclicity. Endocrinology: Ovarian response in consecutive cycles of ovarian stimulation in normally ovulating women.
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Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics. Citing articles via Web of Science 8. Most Read Most Cited Bleeding patterns after vaginal misoprostol for treatment of early pregnancy failure. Right-sided ovulation favours pregnancy more than left-sided ovulation. FSH is vital to fertility. Your fertility doctor can help you determine what the cause might be, but your high FSH levels could be the result of a number of conditions including: Premature menopause.
Premature ovarian failure. My FSH level is normal, so that factor is definitely not the problem. This is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Gonadotropins then go on to act on the ovaries. The pituitary gland produces FSH which acts on the ovaries to stimulate the growth of follicles containing your eggs.
As well as growing the ovarian follicles, FSH stimulates the granulosa cells that surround the follicle to produce oestrogen, an essential hormone for regulating the menstrual cycle 1. You can read more about oestrogen here. Oestrogen is essential for regulating the menstrual cycle and for reproductive health.
When FSH reaches the ovaries, it acts on granulosa cells to produce an enzyme called aromatase, which then converts androgens testosterone which were released from nearby cells, into oestradiol E 2 , a form of oestrogen 2. The eggs in your ovaries start off as immature. Each month, a number of them start a maturation process in response to hormones, and the most mature egg is released from the ovary into the fallopian tube in a process called ovulation.
One of the hormones involved in the maturation process is FSH 2. Increasing FSH levels in the early stages of your menstrual cycle leads to more E 2, which has a negative feedback effect on FSH levels. In other words, when you have lots of E 2 it feeds back to the region of the brain that released the FSH and tells it to stop. The remaining follicles disintegrate. A surge in the hormone LH, therefore, causes the follicle to rupture, releasing the egg into the fallopian tube in the process of ovulation 3,4.
After ovulation, the empty follicle that once contained the egg produces the hormone progesterone to support conception, implantation and the early stages of pregnancy. The high levels of progesterone prevent the release of more FSH from the pituitary gland. The empty follicle breaks down if no embryo implants into the lining of the uterus.
This causes a drop in progesterone which allows for FSH production to start again at the beginning of the next menstrual cycle 5.
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